A 3-note sequence through the pentatonic scale — sounds musical immediately and is used by every great guitarist.
e|--5--8--5--8--7--5--8--7--5--| B|--5--8--5--8--7--5--8--7--5--| G|--5--7--5--7--5--7--5--7--5--|
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Instead of playing the scale straight up, you play 3 notes up, then 1 note back, then 3 notes up again. This creates a cascading, flowing sound that's much more musical than a straight scale run.